Hold your shares and allow them to grow. However, if you need to take some money out of market periodically for a use such as college admission fee, sell just a few shares when the price is 25% to 30 % up and keep the amount in bank. But don’t sell your best performing shares.
If you can fight off the temptation to sell your best shares you'll be rewarded in the long run.
If you want to learn more check out these resources: